Distinct peak at 3.8 ppm observed by 3T MR spectroscopy in meningiomas, while nearly absent in high-grade gliomas and cerebral metastases | Zendy

Evanthia Kousi | Zendy; Ioannis Tsougos | Zendy; Konstantinos Fountas | Zendy; Kiriaki Theodorou | Zendy; Evaggelia Tsolaki | Zendy; Ioannis Fezoulidis | Zendy; E. Kapsalaki | Zendy

Open Access

Distinct peak at 3.8 ppm observed by 3T MR spectroscopy in meningiomas, while nearly absent in high-grade gliomas and cerebral metastases

Author(s) -

Evanthia Kousi,

Ioannis Tsougos,

Konstantinos Fountas,

Kiriaki Theodorou,

Evaggelia Tsolaki,

Ioannis Fezoulidis,

E. Kapsalaki

Publication year - 2012

Publication title -

molecular medicine reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.727

H-Index - 56

eISSN - 1791-3004

pISSN - 1791-2997

DOI - 10.3892/mmr.2012.773

Subject(s) - meningioma , oncogene , malignancy , proton magnetic resonance , pathology , glioma , magnetic resonance imaging , cancer , nuclear magnetic resonance , medicine , nuclear medicine , biology , cell cycle , chemistry , cancer research , radiology , physics

The purpose of the present study was to evaluate distinct metabolic features of meningiomas to distinguish them from other brain lesions using proton magnetic resonance spectroscopy. The study was performed on 17 meningiomas, 24 high-grade gliomas and 9 metastases. Elevated signal intensity at 3.8 ppm observed in low TE spectra adequately differentiated meningioma from other brain tumors while alanine was not indicative of meningioma occurrence; the presence of lipids and lactate did not provide a strong index for meningioma malignancy.

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