Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report | Zendy

Hirotaka Noda | Zendy; Kazuyoshi Masuda | Zendy; Masami Kanbara | Zendy; Hiromi Maeda | Zendy; Tadao K. Kobayashi | Zendy; Chikao Yutani | Zendy

Open Access

Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report

Author(s) -

Hirotaka Noda,

Kazuyoshi Masuda,

Masami Kanbara,

Hiromi Maeda,

Tadao K. Kobayashi,

Chikao Yutani

Publication year - 2020

Publication title -

molecular and clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.442

H-Index - 7

eISSN - 2049-9469

pISSN - 2049-9450

DOI - 10.3892/mco.2020.2030

Subject(s) - gastrinoma , duodenal bulb , duodenum , neuroendocrine tumors , malignancy , medicine , gastroenterology , cytopathology , surgical oncology , gastrin , pathology , cytology , secretion

Sporadic gastrin-producing neuroendocrine tumors (NETs) of the duodenum present with either Zollinger-Ellison syndrome or unspecific syndromes. Ki-67 scoring in cytopathology is an alternative approach for establishing the gastrinoma grade. Although the majority of NETs, including gastrinomas, occur in the duodenum, most research regarding the Ki-67 index is focused on tumors of pancreatic origin. To the best of our knowledge, there is no study on the Ki-67 index for cytological analysis of duodenal gastrinoma. The current report presents two cases of a 56-year-old man and a 66-year-old woman with NET G1 and G2 gastrinoma, respectively, arising in the duodenal bulb. The present report focused on the differences in nuclear pleomorphism and Ki-67 index between these two cases.

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