Evaluation of the prognostic utility of the combination of platelet count with mean platelet volume as a prognostic indicator in head and neck cancer | Zendy

Tristan Tham | Zendy; Edric Leung | Zendy; Caitlin Olson | Zendy; Michael Wotman | Zendy; Julian Khaymovich | Zendy; Josephine R. Coury | Zendy; Sireesha Teegala | Zendy; Peter Costantino | Zendy

Open Access

Evaluation of the prognostic utility of the combination of platelet count with mean platelet volume as a prognostic indicator in head and neck cancer

Author(s) -

Tristan Tham,

Edric Leung,

Caitlin Olson,

Michael Wotman,

Julian Khaymovich,

Josephine R. Coury,

Sireesha Teegala,

Peter Costantino

Publication year - 2019

Publication title -

molecular and clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.442

H-Index - 7

eISSN - 2049-9469

pISSN - 2049-9450

DOI - 10.3892/mco.2019.1813

Subject(s) - mean platelet volume , medicine , head and neck cancer , proportional hazards model , oncology , multivariate analysis , cancer , univariate analysis , stage (stratigraphy) , retrospective cohort study , survival analysis , multivariate statistics , platelet , biology , paleontology , statistics , mathematics

The combination of platelet count to mean platelet volume (COP-MPV) has been recently reported as a prognostic indicator of oral cavity cancer and other cancer sites. The aim of the present study was to validate the utility of the COP-MPV as a prognostic indicator in all head and neck cancer (HNC) sites. The clinicopathological characteristics of the COP-MPV with HNC were also investigated. This is a retrospective cohort study that recruited consecutively treated patients at a tertiary level academic hospital. Clinicopathological characteristics were recorded, including the COP-MPV scores. Survival was analyzed using Kaplan-Meier analysis, as well as multivariate Cox Proportional Hazards regression. COP-MPV was not associated with the survival outcome in univariate or multivariate analysis. In the multivariate model, tumor differentiation, tumor stage, nodal stage, surgical margins and hemoglobin were revealed to be significantly associated with survival. The results demonstrated that the COP-MPV is not a suitable prognostic factor for HNC.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research