Characteristics of colorectal cancer diagnosed with screening abdominal ultrasonography | Zendy

M. Tomizawa | Zendy; Fuminobu Shinozaki | Zendy; Rumiko Hasegawa | Zendy; Kazunori Fugo | Zendy; Yoshinori Shirai | Zendy; Yasufumi Motoyoshi | Zendy; Takao Sugiyama | Zendy; Shigenori Yamamoto | Zendy; Takashi Kishimoto | Zendy; Naoki Ishige | Zendy

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Characteristics of colorectal cancer diagnosed with screening abdominal ultrasonography

Author(s) -

M. Tomizawa,

Fuminobu Shinozaki,

Rumiko Hasegawa,

Kazunori Fugo,

Yoshinori Shirai,

Yasufumi Motoyoshi,

Takao Sugiyama,

Shigenori Yamamoto,

Takashi Kishimoto,

Naoki Ishige

Publication year - 2016

Publication title -

molecular and clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.442

H-Index - 7

eISSN - 2049-9469

pISSN - 2049-9450

DOI - 10.3892/mco.2016.903

Subject(s) - medicine , colorectal cancer , carcinoembryonic antigen , colonoscopy , abdominal ultrasound , ultrasound , abdominal wall , cancer , receiver operating characteristic , ultrasonography , abdominal ultrasonography , gastroenterology , radiology , surgery

Patient records were retrospectively analyzed to elucidate the characteristics of patients with colorectal cancer (CRC) diagnosed with screening abdominal ultrasound (US). Patients diagnosed with CRC using abdominal US [localized irregular wall thickening (W) or a hypoechoic mass with a hyperechoic mass (M)] were enrolled. The patients were subjected to colonoscopy and treated surgically between March, 2010 and January, 2015. A total of 5 men (aged 74.0±0.8 years) and 10 women (aged 73.0±12.0 years) were analyzed. Stratification was analyzed with abdominal US. The threshold value of wall thickness to diagnose CRC was investigated with receiver operating characteristic (ROC) curve analysis. The average wall thickness was 2.8±0.4 mm in the surrounding normal tissue and 12.7±5.2 mm in CRC (one-way analysis of variance, P<0.0001). The wall was significantly thicker in CRC compared with the normal colonic wall. The calculated threshold value was 4.3 mm for the diagnosis of CRC. Stratification was preserved in W, while it was lost in M (Chi-squared test, P=0.0196). The hemoglobin concentration was lower, while the C-reactive protein, carcinoembryonic antigen and carbohydrate antigen 19-9 levels were elevated above normal values. The threshold value was 4.3 mm for the diagnosis of CRC with abdominal US.

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