Maximum standardized uptake value in 18F-fluoro-2-deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer | Zendy

Takeshi Kajiwara | Zendy; Yoichi Hiasa | Zendy; Tomohiro Nishina | Zendy; Toshihiko Matsumoto | Zendy; Shinichiro Hori | Zendy; Seijin Nadano | Zendy; Haruo Iguchi | Zendy; Satoru Takeji | Zendy; Eiji Tsubouchi | Zendy; Yoshio Ikeda | Zendy; Morikazu Onji | Zendy

Open Access

Maximum standardized uptake value in 18F-fluoro-2-deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer

Author(s) -

Takeshi Kajiwara,

Yoichi Hiasa,

Tomohiro Nishina,

Toshihiko Matsumoto,

Shinichiro Hori,

Seijin Nadano,

Haruo Iguchi,

Satoru Takeji,

Eiji Tsubouchi,

Yoshio Ikeda,

Morikazu Onji

Publication year - 2014

Publication title -

molecular and clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.442

H-Index - 7

eISSN - 2049-9469

pISSN - 2049-9450

DOI - 10.3892/mco.2014.238

Subject(s) - positron emission tomography , esophageal cancer , cancer , deoxyglucose , standardized uptake value , oncogene , molecular medicine , tomography , nuclear medicine , medicine , cell cycle , radiology

Positron emission tomography/computed tomography (PET/CT) with 18 F-fluoro-2-deoxyglucose (FDG-PET/CT) has become established in cancer imaging, and derived maximum standardized uptake values (SUVmax) add functional information regarding cancer, including esophageal squamous cell carcinoma (ESCC). The aim of the present study was to determine the clinical significance and association of tumor progression using SUVmax derived from PET/CT images in patients with ESCC. In total, 101 patients with ESCC were assessed using FDG-PET/CT and the SUVmax was then compared with the clinical backgrounds and prognoses of the patients. Endoscopic ESCC biopsy specimens were obtained in order to analyze mRNA expression relative to tumor progression. The results showed that values for SUVmax were significantly higher in patients with tumor progression factors, particularly those with lymph node metastasis. Analysis of receiver operating characteristics curves revealed an optimum SUVmax cut-off value of 10.26 for node-positive disease. Patients with SUVmax ≥10.26 had gene alterations with epithelial-mesenchymal transition (EMT) and significantly worse overall survival (P=0.0012). A higher SUVmax in patients with ESCC was associated with lymph node metastasis and a poorer prognosis. Thus, the SUVmax may reflect the potential of EMT in patients with ESCC.

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