Implications of nestin in breast cancer pathogenesis (Review) | Zendy

Aleksandra Nowak | Zendy; Piotr Dzięgiel | Zendy

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Implications of nestin in breast cancer pathogenesis (Review)

Author(s) -

Aleksandra Nowak,

Piotr Dzięgiel

Publication year - 2018

Publication title -

international journal of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.405

H-Index - 122

ISSN - 1019-6439

DOI - 10.3892/ijo.2018.4441

Subject(s) - nestin , myoepithelial cell , biology , breast cancer , pathogenesis , pathology , oncogene , cancer research , stem cell , metastasis , cancer , neural stem cell , cell cycle , immunohistochemistry , microbiology and biotechnology , immunology , medicine , genetics

The aim of the present review was to summarize the current knowledge of the involvement of nestin in breast cancer (BC) pathogenesis. Nestin is a member of the class VI family of intermediate filament proteins, originally identified as a marker of neural stem cells and subsequently demonstrated to be expressed in BC and other cancer types. In normal breast tissue, nestin is expressed in the basal/myoepithelial cells of the mammary gland. In BC, nestin identifies basal-like tumours and predicts aggressive behaviour and poor prognosis. Nestin expression has also been detected in BC stem cells and newly-formed tumour vessels, being a factor in promoting invasion and metastasis. The present review provides an up-to-date overview of the involvement of nestin in processes facilitating BC pathogenesis and progression.

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