Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells | Zendy

Lian Hui | Zendy; Jingru Zhang | Zendy; Xiaoxu Ding | Zendy; Xing Guo | Zendy; Xuejun Jiang | Zendy

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Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells

Author(s) -

Lian Hui,

Jingru Zhang,

Xiaoxu Ding,

Xing Guo,

Xuejun Jiang

Publication year - 2017

Publication title -

international journal of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.405

H-Index - 122

ISSN - 1019-6439

DOI - 10.3892/ijo.2017.3877

Subject(s) - sox2 , cancer research , oncogene , cisplatin , apoptosis , cancer cell , cell cycle , cell growth , extracellular matrix , matrix (chemical analysis) , microbiology and biotechnology , biology , cancer , chemistry , medicine , biochemistry , chemotherapy , embryonic stem cell , gene , chromatography

Increasing evidence shows that matrix stiffness plays a critical role in affecting the phenotype and behavior of tumor cells. We report that matrix stiffness significantly regulated the proliferation and chemotherapeutic response of Hep-2 cells. Increasing substrate stiffness promotes the proliferation of Hep-2 cells. When cultured on soft gels, Hep-2 cells expressed higher level of stem cell markers. Following treatment with cisplatin or 5-FU, we observed reduced apoptosis in Hep-2 cells cultured on soft supports. Sox2 is essential for the chemoresistance of Hep-2 cells cultured in soft stiffness. Our results demonstrated that Sox2 promotes chemoresistance of Hep-2 cells in soft stiffness via upregulating the expression of ABCG2. Our findings will provide a new platform for the future design of anticancer drugs based on the biophysical properties of the tumor site.

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