Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer | Zendy

Phung Manh Thang | Zendy; Atsushi Takano | Zendy; Yoshihiro Yoshitake | Zendy; Masanori Shinohara | Zendy; Yoshinori Murakami | Zendy; Yataro Daigo | Zendy

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Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer

Author(s) -

Phung Manh Thang,

Atsushi Takano,

Yoshihiro Yoshitake,

Masanori Shinohara,

Yoshinori Murakami,

Yataro Daigo

Publication year - 2016

Publication title -

international journal of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.405

H-Index - 122

ISSN - 1019-6439

DOI - 10.3892/ijo.2016.3649

Subject(s) - biomarker , cell cycle , oncogene , cancer , molecular medicine , apoptosis , cancer research , oncology , gene knockdown , small interfering rna , immunohistochemistry , biology , medicine , rna , gene , biochemistry

Oral cavity carcinoma (OCC) is one of the most common causes of cancer-related death worldwide and has poor clinical outcome after standard therapies. Therefore, new prognostic biomarkers and therapeutic targets for OCC are urgently needed. We selected cell division cycle associated 1 (CDCA1) as a candidate OCC biomarker. Immunohistochemical analysis confirmed that CDCA1 protein was expressed in 67 of 99 OCC tissues (67.7%), but not in healthy oral epithelia. CDCA1 expression was significantly associated with poor prognosis in OCC patients (P=0.0244). Knockdown of CDCA1 by siRNAs significantly increased apoptosis of tumor cells. These data suggest that CDCA1 represents a novel prognostic biomarker and therapeutic target for OCC.

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