The role of Src family kinases in growth and migration of glioma stem cells | Zendy

Xiaosi Han | Zendy; Wenbin Zhang | Zendy; Xiuhua Yang | Zendy; Crystal G. Wheeler | Zendy; Catherine P. Langford | Zendy; Lu Wu | Zendy; Natalia Filippova | Zendy; Gregory K. Friedman | Zendy; Qiang Ding | Zendy; Hassan M. FathallahShaykh | Zendy; G. Yancey Gillespie | Zendy; Burt Nabors | Zendy

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The role of Src family kinases in growth and migration of glioma stem cells

Author(s) -

Xiaosi Han,

Wenbin Zhang,

Xiuhua Yang,

Crystal G. Wheeler,

Catherine P. Langford,

Lu Wu,

Natalia Filippova,

Gregory K. Friedman,

Qiang Ding,

Hassan M. FathallahShaykh,

G. Yancey Gillespie,

Burt Nabors

Publication year - 2014

Publication title -

international journal of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.405

H-Index - 122

ISSN - 1019-6439

DOI - 10.3892/ijo.2014.2432

Subject(s) - biology , oncogene , kinase , proto oncogene tyrosine protein kinase src , cell cycle , stem cell , cancer research , molecular medicine , microbiology and biotechnology , cancer , genetics

Src family kinases (SFKs) are highly expressed and active in clinical glioblastoma multiforme (GBM) specimens. SFKs inhibitors have been demonstrated to inhibit proliferation and migration of glioma cells. However, the role of SFKs in glioma stem cells (GSCs), which are important for treatment resistance and recurrence, has not been reported. Here, we examined the expression pattern of individual members of SFKs and their functional role in CD133⁺ GSCs in comparison to primary glioma cells. We found that Fyn, c-Src and Yes were robustly expressed in GSCs while Lck was absent. Knockdown of c-Src, Yes or treatment with the SFK inhibitor dasatinib inhibited the migration of GSCs, but had no impact on their growth or self-renewal. These results suggest that SFKs represent an effective target for GSC migration but not for their growth.

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