The metastasis suppressor SOX11 is an independent prognostic factor for improved survival in gastric cancer | Zendy

Ying Qu | Zendy; Chenfei Zhou | Zendy; Jianian Zhang | Zendy; Qu Cai | Zendy; Jianfang Li | Zendy; Tao Du | Zendy; Zhenggang Zhu | Zendy; Xiaojiang Cui | Zendy; Bingya Liu | Zendy

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The metastasis suppressor SOX11 is an independent prognostic factor for improved survival in gastric cancer

Author(s) -

Ying Qu,

Chenfei Zhou,

Jianian Zhang,

Qu Cai,

Jianfang Li,

Tao Du,

Zhenggang Zhu,

Xiaojiang Cui,

Bingya Liu

Publication year - 2014

Publication title -

international journal of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.405

H-Index - 122

ISSN - 1019-6439

DOI - 10.3892/ijo.2014.2328

Subject(s) - cancer , oncogene , cancer research , cell cycle , metastasis , biology , oncology , apoptosis , cell , cancer cell , medicine , pathology , biochemistry , genetics

SOX11 is involved in gastrulation and in malignant diseases. The aim of this study was to investigate the role of SOX11 in gastric cancer and its expression pattern and clinical significance. SOX11 overexpression cell model was used to examine in vitro and in vivo the role of SOX11 in cell growth and metastasis. Cell cycle analysis and Annexin V/PI double staining were used to investigate the effect of SOX11 on cell cycle progression and apoptosis. The expression of SOX11 in human gastric cancer was examined by immunohistochemistry. The correlation of SOX11 expression with clinicopathological characteristics and survival of patients was analyzed by Pearson's χ(2) and Kaplan-Meier analyses, respectively. Cox's proportional hazard model was employed in multivariate analysis. SOX11 overexpression did not inhibit cell growth but strongly suppressed cell migration/invasion in vitro and in vivo. We found a significant correlation between high SOX11 protein levels and Lauren's classification (intestinal type), differentiation status (high and medium), and early TNM stage. SOX11 is an independent prognostic factor for improved survival in gastric cancer patients. SOX11 was a potential tumor-suppressor and an independent positive prognostic factor in gastric cancer patients with less advanced clinicopathological features.

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