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Resveratrol (3,4',5 tri-hydroxystilbene), a natural plant polyphenol, hasgained interest as a non-toxic chemopreventive agent capable of inducing tumorcell death in a variety of cancer types. Several studies were undertaken to obtainsynthetic analogues of resveratrol with potent anticancer activity. The aim ofthe present study was to investigate the effect of HS-1793 as a new resveratrolanalog on apoptosis via the mitochondrial pathway in murine breast cancer cells.A pharmacological dose (1.3-20 µM) of HS-1793 exerted a cytotoxic effect on murinebreast cancer cells resulting in apoptosis. HS-1793-mediated cytotoxicity in FM3Acells by several apoptotic events including mitochondrial cytochrome c release,activation of caspase-3 and PARP occurred. In addition, HS-1793 induced collapseof ∆Ψm and enhanced AIF and Endo G release from mitochondria while undergoingapoptosis. These results demonstrate that the cytotoxicity by HS-1793 in FM3Acells can mainly be attributed to apoptosis via a mitochondrial pathway by caspaseactivation or contributions of AIF and Endo G.

The novel resveratrol analogue HS-1793 induces apoptosis via the mitochondrial pathway in murine breast cancer cells