Tripchlorolide induces cell death in lung cancer cells by autophagy | Zendy

Limin Chen | Zendy; Qing Liu | Zendy; Zhenghui Huang | Zendy; Feng Wu | Zendy; Zhiying Li | Zendy; Xiangqi Chen | Zendy; Tingyan Lin | Zendy

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Tripchlorolide induces cell death in lung cancer cells by autophagy

Author(s) -

Limin Chen,

Qing Liu,

Zhenghui Huang,

Feng Wu,

Zhiying Li,

Xiangqi Chen,

Tingyan Lin

Publication year - 2011

Publication title -

international journal of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.405

H-Index - 122

ISSN - 1019-6439

DOI - 10.3892/ijo.2011.1278

Subject(s) - autophagy , apoptosis , a549 cell , triptolide , oncogene , programmed cell death , microbiology and biotechnology , cell cycle , biology , cancer research , in vivo , cell , cancer cell , cell growth , lung cancer , in vitro , cancer , medicine , biochemistry , genetics

It has been demonstrated that triptolide inhibits the growth of severaltypes of cancer cells in vitro and prevents tumor growth in vivo by inducing apoptosisand autophagy. Here we showed that Tripchlorolide (T4) significantly suppressedthe proliferation of A549 cells in a dose- and time-dependent manner. This suppressiveeffect was diminished when cells were pretreated with 3-Methylamphetamine (3-MA).After the cells were treated with T4, the LC3 II protein expression was significantlyincreased, and autophagosomes were observed by TEM. However, almost no apoptosiswas observed in A549 treated with T4. These results suggest that T4 induces A549cell death predominantly through the activation of the autophagy pathway insteadof the apoptosis pathway.

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