Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine | Zendy

Ki Mo Lee | Zendy; Haeng-A. Kang | Zendy; Chang-Bo Ko | Zendy; Eunha Oh | Zendy; Min Jung Park | Zendy; Hwa-Youn Lee | Zendy; Harim Choi | Zendy; ChulHo Yun | Zendy; WoonWon Jung | Zendy; JaeWook Oh | Zendy; HyungSik Kang | Zendy

Open Access

Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine

Author(s) -

Ki Mo Lee,

Haeng-A. Kang,

Chang-Bo Ko,

Eunha Oh,

Min Jung Park,

Hwa-Youn Lee,

Harim Choi,

ChulHo Yun,

WoonWon Jung,

JaeWook Oh,

HyungSik Kang

Publication year - 2012

Publication title -

international journal of molecular medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.048

H-Index - 90

eISSN - 1791-244X

pISSN - 1107-3756

DOI - 10.3892/ijmm.2012.1183

Subject(s) - enalapril , nifedipine , pharmacology , medicine , microarray , molecular medicine , gene expression , pathogenesis , microarray analysis techniques , gene , biology , endocrinology , cell cycle , angiotensin converting enzyme , blood pressure , cancer , genetics , calcium

Enalapril and nifedipine are used as antihypertensive drugs; however, thetherapeutic target molecules regulated by enalapril and nifedipine have yet tobe fully identified. The aim of this study was to identify novel target genesthat are specifically regulated by enalapril and nifedipine in tissues from spontaneouslyhypertensive rats (SHR) using DNA microarray analysis. We found that administrationof SHR with enalapril and nifedipine differentially regulated 33 genes involvedin the pathogenesis of cardiovascular diseases. Furthermore, we identified 16genes that have not previously been implicated in cardiovascular diseases, includinginterleukin-24 (IL-24). Among them, exogenous administration of IL-24 attenuatedthe expression of vascular inflammation and hypertension-related genes inducedby H2O2 treatment in mouse vascular smooth muscle (MOVAS) cells. This study providesvaluable information for the development of novel antihypertensive drugs. In addition,the genes identified may be of use as biomarkers and therapeutic targets for cardiovasculardiseases, including hypertension.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research