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Enalapril and nifedipine are used as antihypertensive drugs; however, thetherapeutic target molecules regulated by enalapril and nifedipine have yet tobe fully identified. The aim of this study was to identify novel target genesthat are specifically regulated by enalapril and nifedipine in tissues from spontaneouslyhypertensive rats (SHR) using DNA microarray analysis. We found that administrationof SHR with enalapril and nifedipine differentially regulated 33 genes involvedin the pathogenesis of cardiovascular diseases. Furthermore, we identified 16genes that have not previously been implicated in cardiovascular diseases, includinginterleukin-24 (IL-24). Among them, exogenous administration of IL-24 attenuatedthe expression of vascular inflammation and hypertension-related genes inducedby H2O2 treatment in mouse vascular smooth muscle (MOVAS) cells. This study providesvaluable information for the development of novel antihypertensive drugs. In addition,the genes identified may be of use as biomarkers and therapeutic targets for cardiovasculardiseases, including hypertension.

Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine