Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo | Zendy

Hui Li | Zendy; Weijue Xu | Zendy; Yimin Huang | Zendy; Xiong Huang | Zendy; Ling-cang Xu | Zendy; Zhibao Lv | Zendy

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Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo

Author(s) -

Hui Li,

Weijue Xu,

Yimin Huang,

Xiong Huang,

Ling-cang Xu,

Zhibao Lv

Publication year - 2012

Publication title -

international journal of molecular medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.048

H-Index - 90

eISSN - 1791-244X

pISSN - 1107-3756

DOI - 10.3892/ijmm.2012.1118

Subject(s) - genistein , carcinogenesis , neuroblastoma , in vivo , cancer research , biology , dnmt3b , oncogene , dna methylation , methylation , epigenetics , methyltransferase , cancer , cell growth , cell cycle , medicine , endocrinology , cell culture , gene expression , dna , gene , biochemistry , genetics

Neuroblastoma (NB) is a type of tumor usually found in children under 5years of age, which originates from lesions in the nervous system and has fastgrowth and early transformation characteristics. Similar to other cancer types,some typical tumor suppressor genes (TSGs), such as P53 and CHD5 are silencedin NB because of high methylation at promoter zones. In the present study, ourresults showed that genistein, an element found in soy, is an epigenetic modifierable to decrease hypermethylation levels of CHD5, and enhances the expressionof CHD5 as well as p53, possibly contributing to inhibition of NB growth in vivoand tumor microvessel formation. Furthermore, genistein acts as a DNA methyltransferase(DNMT) inhibitor to significantly decrease the expression of DNMT3b. Our studyindicates that genistein plays an important role in inhibiting NB growth in vivo,probably preventing tumorigenesis risk as a kind of therapeutic agent for NB treatmentin the future.

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