Clinicopathological significance of forkhead box protein A1 in breast cancer: A meta-analysis | Zendy

Keli He | Zendy; Hui Zeng | Zendy; Xianqun Xu | Zendy; Anling Li | Zendy; Qing Cai | Zendy; Xinghua Long | Zendy

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Clinicopathological significance of forkhead box protein A1 in breast cancer: A meta-analysis

Author(s) -

Keli He,

Hui Zeng,

Xianqun Xu,

Anling Li,

Qing Cai,

Xinghua Long

Publication year - 2016

Publication title -

experimental and therapeutic medicine

Language(s) - English

Resource type - Journals

eISSN - 1792-1015

pISSN - 1792-0981

DOI - 10.3892/etm.2016.3229

Subject(s) - breast cancer , oncogene , molecular medicine , oncology , cell cycle , meta analysis , cancer research , cancer , biology , forkhead transcription factors , medicine , genetics , regulation of gene expression , gene

The aim of the present study was to investigate the associations between the expression of forkhead box protein A1 (FOXA1) and differential clinicopathological characteristics in breast cancer using a meta-analysis method. Eligible studies that investigated the correlation between FOXA1 expression and the clinical characteristics of breast cancer were collected through searching numerous databases, including PubMed, EMBASE, the Chinese National Knowledge Infrastructure and the VIP database. In total, eight studies were included in the meta-analysis. Following a systematic analysis, the expression of FOXA1 was found to be significantly associated with the estrogen receptor α status, the progesterone receptor status, lymph node metastasis and the histological grade in breast cancer. However, no statistically significant association was observed between FOXA1 expression and the human epidermal growth factor receptor-2 status in breast cancer patients.

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