Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats | Zendy

Ye Tian | Zendy; Lirong Teng | Zendy; Zhenzuo Wang | Zendy; Min Zhao | Zendy; Qingfan Meng | Zendy; Jiahui Lü | Zendy; Jianming Tian | Zendy; Weiwei Zhang | Zendy; Xiaoyi Zheng | Zendy; Di Wang | Zendy; Lesheng Teng | Zendy

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Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats

Author(s) -

Ye Tian,

Lirong Teng,

Zhenzuo Wang,

Min Zhao,

Qingfan Meng,

Jiahui Lü,

Jianming Tian,

Weiwei Zhang,

Xiaoyi Zheng,

Di Wang,

Lesheng Teng

Publication year - 2015

Publication title -

experimental and therapeutic medicine

Language(s) - English

Resource type - Journals

eISSN - 1792-1015

pISSN - 1792-0981

DOI - 10.3892/etm.2015.2426

Subject(s) - medicine , analgesic , cancer pain , h&e stain , tail flick test , morphine , cancer , chronic pain , toxicity , pharmacology , anorexia , addiction , pill , physiology , traditional medicine , nociception , immunohistochemistry , physical therapy , receptor , psychiatry

Jia-Yuan-Qing pill (JYQP) composed of Porcellio laevis Latreille, Corydalis Rhizoma and Radix Cynanchi Paniculati at a ratio of 9:7:7 has been found to be an effective analgesic agent. The present study aimed to evaluate the safety, addictive potential and anti-cancer pain activity of JYQP in a rat model. During the 6-month chronic toxicity test, no significant changes in general behavior, defecation, postural abnormalities, dietary or water intake or blood biochemical parameters were observed in male and female rats. Although a high dose of JYQP (5 g/kg) caused swelling of the liver, spleen and kidney in male and female rats, no pathological changes were observed in all organs examined via hematoxylin and eosin staining. The analgesic effect of JYQP on bone cancer pain was successfully confirmed in a rat model of Walker 256 cell-induced bone cancer. In contrast to morphine, in a physical dependence test, JYQP produced no withdrawal symptoms following chronic administration. The data from this study provide experimental evidence supporting the clinical use of JYQP as an effective, safe and non-addictive agent for the treatment of bone cancer pain.

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