Association between EML4-ALK fusion gene and thymidylate synthase mRNA expression in non-small cell lung cancer tissues | Zendy

C. Xu | Zendy; Gang Wang | Zendy; WU-LONG WANG | Zendy; Wenbin Gao | Zendy; Chuan-Jun Han | Zendy; Jingshan Gao | Zendy; Liying Zhang | Zendy; Yang Li | Zendy; Lin Wang | Zendy; YU-PING ZHANG | Zendy; Yuwang Tian | Zendy; Dongdong Qi | Zendy

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Association between EML4-ALK fusion gene and thymidylate synthase mRNA expression in non-small cell lung cancer tissues

Author(s) -

C. Xu,

Gang Wang,

WU-LONG WANG,

Wenbin Gao,

Chuan-Jun Han,

Jingshan Gao,

Liying Zhang,

Yang Li,

Lin Wang,

YU-PING ZHANG,

Yuwang Tian,

Dongdong Qi

Publication year - 2015

Publication title -

experimental and therapeutic medicine

Language(s) - English

Resource type - Journals

eISSN - 1792-1015

pISSN - 1792-0981

DOI - 10.3892/etm.2015.2372

Subject(s) - thymidylate synthase , fusion gene , lung cancer , anaplastic lymphoma kinase , pemetrexed , cancer research , biology , gene expression , oncogene , gene , cancer , microbiology and biotechnology , cell cycle , chemotherapy , medicine , oncology , genetics , fluorouracil , malignant pleural effusion , cisplatin

This study aimed to investigate the association of the mRNA expression of the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene with that of thymidylate synthase (TYMS) in non-small cell lung cancer (NSCLC) tissues. Quantitative polymerase chain reaction was used to detect the expression of EML4-ALK fusion gene and TYMS mRNA in 257 cases of NSCLC. The positive rate of EML4-ALK fusion gene was 4.28% in the NSCLC tissues (11/257), and was higher in nonsmokers than in smokers (P<0.05); TYMS mRNA expression was detected in 63.42% (163/257) of cases. An association of the EML4-ALK fusion gene with TYMS expression was detected; a low expression level of TYMS mRNA was observed more frequently when the EML4-ALK fusion gene was present than when it was not detected (P<0.05). In conclusion, patients positive for the EML4-ALK fusion gene in NSCLC tissues are likely to have a low expression level of TYMS, and may benefit from the first-line chemotherapy drug pemetrexed.

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