Protective effect of exogenous matrix metalloproteinase-9 on chronic renal failure | Zendy

Lei Wang | Zendy; Jue Wang | Zendy; Yong Wang | Zendy; Qiang Fu | Zendy; YONG-HUA LEI | Zendy; ZHI-YONG NIE | Zendy; Jianxin Qiu | Zendy; Bao Ting-yi | Zendy

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Protective effect of exogenous matrix metalloproteinase-9 on chronic renal failure

Author(s) -

Lei Wang,

Jue Wang,

Yong Wang,

Qiang Fu,

YONG-HUA LEI,

ZHI-YONG NIE,

Jianxin Qiu,

Bao Ting-yi

Publication year - 2013

Publication title -

experimental and therapeutic medicine

Language(s) - English

Resource type - Journals

eISSN - 1792-1015

pISSN - 1792-0981

DOI - 10.3892/etm.2013.1409

Subject(s) - matrix metalloproteinase , creatinine , molecular medicine , oncogene , kidney , blood urea nitrogen , extracellular matrix , chronic renal failure , medicine , endocrinology , matrix metalloproteinase 9 , renal function , kidney disease , tissue inhibitor of metalloproteinase , biology , cancer , cell cycle , microbiology and biotechnology

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have pivotal functions in extracellular matrix turnover and are involved in chronic kidney diseases. However, the exact functions of MMPs in chronic renal failure (CRF) have yet to be demonstrated. The aim of the present study was to examine the effects of MMP-9 on CRF. An adenine-induced model of CRF was generated in rabbits. Following the injection of MMP-9 into the renal arteries of the rabbits, significant improvements in renal morphology and serum levels of creatinine and urea nitrogen were observed. Furthermore, MMP-9 administration was shown to decrease the serum TIMP-1 concentration and upregulate renal MMP-9 expression. These results demonstrate a directly protective role for MMP-9 in CRF.

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