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This study was designed to evaluate the left ventricular systolic synchronization in patients implanted with dual-chamber DDD mode cardiac pacemakers by real-time three-dimensional echocardiography (RT3DE). Twenty patients implanted with DDD mode cardiac pacemakers for 12 months and 20 healthy subjects underwent RT3DE. This method provided left ventricular end-diastolic volume (LEDV), left ventricular end-systolic volume (LESV), stroke volume (SV), left ventricular ejection fraction (LVEF), the mean value of the time to minimal systolic volume of the 16 left ventricular segments (Tmean), the standard deviation of Tmean (T-SD), the maximal difference of the time to minimal systolic volume of the 16 left ventricular segments (Tmax) and time-volume curves of the 16 left ventricular segments. Results showed that compared with the healthy group, LESV was significantly increased (P&lt;0.05), SV and LVEF were significantly decreased (P&lt;0.05) and T-SD and Tmax were significantly prolonged (P&lt;0.05) in patients implanted with DDD mode cardiac pacemakers. The time to minimal systolic volume of the 16 left ventricular segments time-volume curves differed in patients implanted with DDD mode cardiac pacemakers. Asynchronization of the left ventricular systolic performance in patients implanted with DDD mode cardiac pacemakers was observed. The results showed that RT3DE is a quantitative method used to evaluate left ventricular systolic synchronization.

Use of real-time three-dimensional echocardiography to assess left ventricular systolic synchronization after dual-chamber pacing therapy