Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension | Zendy

Zhaohua Zhang | Zendy; Yan Lu | Zendy; Yun Luan | Zendy; Jingjie Zhao | Zendy

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Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension

Author(s) -

Zhaohua Zhang,

Yan Lu,

Yun Luan,

Jingjie Zhao

Publication year - 2012

Publication title -

experimental and therapeutic medicine

Language(s) - English

Resource type - Journals

eISSN - 1792-1015

pISSN - 1792-0981

DOI - 10.3892/etm.2012.691

Subject(s) - medicine , mesenchymal stem cell , bone marrow , pulmonary artery , hemodynamics , pulmonary hypertension , h&e stain , lumen (anatomy) , lung , pathology , cardiology , staining

The aim of the present study was to investigate the effect of bone marrow mesenchymal stem cell (BMSC) transp1antation on lung and heart damage in a rat model of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). The animals were randomly divided into 3 groups: control, PAH and BMSC implantation groups. Structural changes in the pulmonary vascular wall, such as the pulmonary artery lumen area (VA) and vascular area (TAA) were measured by hematoxylin and eosin (H&E) staining, and the hemodynamics were detected by echocardiography. Two weeks post-operation, our results demonstrated that sublingual vein injection of BMSCs significantly attenuated the pulmonary vascular structural and hemodynamic changes caused by pulmonary arterial hypertension. The mechanism may be executed via paracrine effects.

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