Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review) | Zendy

Kiyoshi Kikuchi | Zendy; Nobuyuki Takeshige | Zendy; Naoki Miura | Zendy; Yoko Morimoto | Zendy; Takashi Ito | Zendy; Salunya Tancharoen | Zendy; Kei Miyata | Zendy; Chiemi Kikuchi | Zendy; NARUMI IIDA | Zendy; Hisaaki Uchikado | Zendy; Naohisa Miyagi | Zendy; Naoto Shiomi | Zendy; Terukazu Kuramoto | Zendy; Ikuro Maruyama | Zendy; Motohiro Morioka | Zendy; Koichi Kawahara | Zendy

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Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review)

Author(s) -

Kiyoshi Kikuchi,

Nobuyuki Takeshige,

Naoki Miura,

Yoko Morimoto,

Takashi Ito,

Salunya Tancharoen,

Kei Miyata,

Chiemi Kikuchi,

NARUMI IIDA,

Hisaaki Uchikado,

Naohisa Miyagi,

Naoto Shiomi,

Terukazu Kuramoto,

Ikuro Maruyama,

Motohiro Morioka,

Koichi Kawahara

Publication year - 2011

Publication title -

experimental and therapeutic medicine

Language(s) - English

Resource type - Journals

eISSN - 1792-1015

pISSN - 1792-0981

DOI - 10.3892/etm.2011.352

Subject(s) - edaravone , free radical scavenger , medicine , stroke (engine) , radical , pharmacology , scavenger , oxidative stress , chemistry , biochemistry , mechanical engineering , engineering

Free radicals play an important role in the pathogenesis of a variety of diseases; thus, they are an attractive target for therapeutic intervention in these diseases. Compounds capable of scavenging free radicals have been developed for this purpose and some, developed for the treatment of cerebral ischemic stroke, have progressed to clinical trials. One such scavenger, edaravone, is used to treat patients within 24 h of stroke. Edaravone, which can diffuse into many disease-affected organs, also shows protective effects in the heart, lung, intestine, liver, pancreas, kidney, bladder and testis. As well as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic and anti-cytokine effects in various diseases. Here, we critically review the literature on its clinical efficacy and examine whether edaravone should be considered a candidate for worldwide development, focusing on its effects on diseases other than cerebral infarction. Edaravone has been safely used as a free radical scavenger for more than 10 years; we propose that edaravone may offer a novel treatment option for several diseases.

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