Association of genetic variants with coronary artery disease and ischemic stroke in a longitudinal population-based genetic epidemiological study | Zendy

Yoshiji Yamada | Zendy; Kota Matsui | Zendy; Ichiro Takeuchi | Zendy; Tetsuo Fujimaki | Zendy

Open Access

Association of genetic variants with coronary artery disease and ischemic stroke in a longitudinal population-based genetic epidemiological study

Author(s) -

Yoshiji Yamada,

Kota Matsui,

Ichiro Takeuchi,

Tetsuo Fujimaki

Publication year - 2015

Publication title -

biomedical reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.607

H-Index - 25

eISSN - 2049-9442

pISSN - 2049-9434

DOI - 10.3892/br.2015.440

Subject(s) - coronary artery disease , medicine , dyslipidemia , stroke (engine) , diabetes mellitus , epidemiology , myocardial infarction , genome wide association study , body mass index , population , genetic epidemiology , disease , genotype , genetics , biology , single nucleotide polymorphism , endocrinology , gene , mechanical engineering , environmental health , engineering

Our previous studies identified nine genes and chromosomal region 3q28 as susceptibility loci for myocardial infarction, ischemic stroke or chronic kidney disease by genome-wide or candidate gene association studies. As coronary artery disease (CAD) and ischemic stroke may share genetic architecture, certain genetic variants may confer susceptibility to the two diseases. The present study examined the association of 13 polymorphisms at these 10 loci with the prevalence of CAD or ischemic stroke in community-dwelling individuals, with the aim of identifying genetic variants that confer susceptibility to the two conditions. Study subjects (170 with CAD, 117 with ischemic stroke and 5,718 controls) were recruited to the Inabe Health and Longevity Study, a longitudinal genetic epidemiological study of atherosclerotic, cardiovascular and metabolic diseases. The subjects were recruited from individuals who visited for an annual health checkup and they were followed up each year (mean follow-up period, 5 years). Longitudinal analysis with a generalized estimating equation, and with adjustment for age, gender, body mass index, smoking status, the prevalence of hypertension, diabetes mellitus and dyslipidemia and the serum concentration of creatinine, revealed that rs2074380 (G→A) and rs2074381 (A→G) of the α-kinase 1 ( ALPK1 ) gene and rs8089 (T→G) of the thrombospondin 2 ( THBS2 ) gene were significantly (P<2×10 -16 ) associated with the prevalence of CAD, with the AA genotype of rs2074380 and GG genotypes of rs2074381 and rs8089 being protective against this condition. Similar analysis revealed that rs9846911 (A→G) at chromosome 3q28, rs2074381 of ALPK1 , rs8089 of THBS2 and rs6046 (G→A) of the coagulation factor VII gene were significantly (P<2×10 -16 ) associated with the prevalence of ischemic stroke, with the GG genotypes of rs9846911, rs2074381 and rs8089 and the AA genotype of rs6046 being protective against this condition. ALPK1 and THBS2 may thus be susceptibility loci for CAD and ischemic stroke.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research