Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2 | Zendy

Xulong Lang | Zendy; Wan Zhong-hai | Zendy; Bu ZhaoYang | Zendy; Xiuran Wang | Zendy; Xiaoxu Wang | Zendy; Lingwei Zhu | Zendy; Jiayu Wan | Zendy; Yang Sun | Zendy; Xinglong Wang | Zendy

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Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2

Author(s) -

Xulong Lang,

Wan Zhong-hai,

Bu ZhaoYang,

Xiuran Wang,

Xiaoxu Wang,

Lingwei Zhu,

Jiayu Wan,

Yang Sun,

Xinglong Wang

Publication year - 2014

Publication title -

biomedical reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.607

H-Index - 25

eISSN - 2049-9442

pISSN - 2049-9434

DOI - 10.3892/br.2014.307

Subject(s) - catabolite repression , streptococcus suis , regulator , cell cycle , oncogene , biology , microbiology and biotechnology , cancer , genetics , gene , virulence , mutant

Streptococcus suis ( S. suis ) type 2 is an extremely important Gram-positive bacterial pathogen that can cause human or swine endocarditis, meningitis, bronchopneumonia, arthritis and sepsis. Catabolite control protein A (CcpA) is a major transcriptional regulator in S. suis type 2 that functions in catabolite control, specifically during growth on glucose or galactose. The regulation of central metabolism can affect the virulence of bacteria. In the present study, a metabolomics approach was used along with principal components analysis (PCA) and partial least-squares-discriminant analysis (PLS-DA) models and 37 metabolites were found that differed substantially between native S. suis and a mutant lacking CcpA. These results showed that CcpA is an important protein in S. suis type 2 for studying bacterial protein function.

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