Anti-inflammatory effects of ozonated water in an experimental mouse model | Zendy

Kazuo Azuma | Zendy; Takuro Mori | Zendy; Kinya Kawamoto | Zendy; Kohei Kuroda | Zendy; Takeshi Tsuka | Zendy; Tomohiro Imagawa | Zendy; Tomohiro Osaki | Zendy; Fumio Itoh | Zendy; Saburo Minami | Zendy; Yoshiharu Okamoto | Zendy

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Anti-inflammatory effects of ozonated water in an experimental mouse model

Author(s) -

Kazuo Azuma,

Takuro Mori,

Kinya Kawamoto,

Kohei Kuroda,

Takeshi Tsuka,

Tomohiro Imagawa,

Tomohiro Osaki,

Fumio Itoh,

Saburo Minami,

Yoshiharu Okamoto

Publication year - 2014

Publication title -

biomedical reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.607

H-Index - 25

eISSN - 2049-9442

pISSN - 2049-9434

DOI - 10.3892/br.2014.290

Subject(s) - ozone , lipopolysaccharide , superoxide dismutase , tumor necrosis factor alpha , inflammation , intraperitoneal injection , chemistry , peritonitis , pharmacology , immunology , medicine , biochemistry , oxidative stress , organic chemistry

Previous studies have suggested that ozonated water is safe and possesses antibacterial effects for treatment of experimental peritonitis rats. In this study, we evaluated the anti-inflammatory effects of ozonated water that was intraperitoneally injected into an experimental inflammatory mouse model. The concentrations of dissolved ozone decreased constantly and lineally, while the half-life of dissolved ozone was 36.8±2.7 min (27°C). The 10-ppm ozonated water was injected intraperitoneally into mice with lipopolysaccharide (LPS)-induced acute inflammation. The results showed that the intraperitoneal injection of ozonated water decreased the levels of tumor necrosis factor-α (TNF-α) and increased the activity of superoxide dismutase (SOD). The results suggest that ozonated water has anti-inflammatory properties and is a potential therapeutic option for acute inflammation.

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