DNA methylation as an early diagnostic marker of cancer (Review) | Zendy

Yuanyuan Dong | Zendy; Haiyang Zhao | Zendy; Haiyan Li | Zendy; Xiaokun Li | Zendy; Shulin Yang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

DNA methylation as an early diagnostic marker of cancer (Review)

Author(s) -

Yuanyuan Dong,

Haiyang Zhao,

Haiyan Li,

Xiaokun Li,

Shulin Yang

Publication year - 2014

Publication title -

biomedical reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.607

H-Index - 25

eISSN - 2049-9442

pISSN - 2049-9434

DOI - 10.3892/br.2014.237

Subject(s) - epigenetics , dna methylation , biology , cancer epigenetics , cancer , genetics , methylation , dna , cancer research , computational biology , gene , gene expression , histone methyltransferase

DNA methylation is one of the essential epigenetic mechanisms that are closely correlated with the mechanisms underlying cell growth, differentiation and transformation in eukaryotes. Global changes in the epigenetic landscape are considered to be a hallmark of cancer. The initiation and progression of cancer are mediated through epigenetic modifications along with genetic alterations. Aberrant methylation of promoter regions is an epigenetic abnormality of the human genome that is highly characteristic of cancer. In this review, we aimed to summarize our current understanding of the alterations in the epigenetic landscape and investigate the potential use of DNA and RNA methylation in effective molecular treatment strategies.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research