Salvianolic acid A positively regulates PTEN protein level and inhibits growth of A549 lung cancer cells | Zendy

Lei Bi | Zendy; Jianping Chen | Zendy; Xiaojing Yuan | Zendy; Zequn Jiang | Zendy; Weiping Chen | Zendy

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Salvianolic acid A positively regulates PTEN protein level and inhibits growth of A549 lung cancer cells

Author(s) -

Lei Bi,

Jianping Chen,

Xiaojing Yuan,

Zequn Jiang,

Weiping Chen

Publication year - 2012

Publication title -

biomedical reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.607

H-Index - 25

eISSN - 2049-9442

pISSN - 2049-9434

DOI - 10.3892/br.2012.33

Subject(s) - pten , oncogene , molecular medicine , cancer , cancer research , cell cycle , lung cancer , apoptosis , a549 cell , cell growth , biology , microbiology and biotechnology , chemistry , medicine , biochemistry , genetics , pi3k/akt/mtor pathway

Salvianolic acid A (Sal A) is an effective compound extracted from Salvia miltiorrhiza which has been used in the treatment of various diseases. Preliminary data indicate that Sal A treatment has a specific anti-lung cancer effect. However, the manner in which Sal A regulates cancer growth remains unknown. In this study, the A549 lung cancer cell line and its response to Sal A treatment was examined. Results showed that Sal A treatment significantly decreased A549 cell growth, promoted partial apoptosis and increased mitochondrial membrane permeability. Western blot analysis showed that Sal A upregulated the phosphatase and tensin homolog (PTEN) protein level, while consistently downregulating Akt phosphorylation. These results indicate that Sal A negatively mediates A549 lung cancer cell line growth or apoptosis, most likely by positively regulating PTEN protein level.

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