Open AccessShort Tandem Repeats Used in Preimplantation Genetic Testing of Β-Thalassemia: Genetic Polymorphisms For 15 Linked Loci in the Vietnamese Population
Author(s) -
Dang Tien Truong,
Ngo Van Nhat Minh,
Dinh Phuong Nhung,
Hoàng Văn Lương,
Quyết Đỗ,
Tran Ngoc Anh,
Son Trinh The,
Nguyễn Thanh Tùng,
Nguyễn Thị Thu Hà,
Duong Thi Phuong Anh,
Le Phuc Hoang,
Nguyen Le Thuy,
Nguyen Thi Mai Hoa,
Nguyen Duy Bac,
Vu Thi Nga,
DinhToi Chu
Publication year - 2019
Publication title -
open access macedonian journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 17
ISSN - 1857-9655
DOI - 10.3889/oamjms.2019.840
Subject(s) - microsatellite , loss of heterozygosity , genetics , thalassemia , medicine , allele , population , vietnamese , multiplex , biology , gene , linguistics , philosophy , environmental health
β-thalassemia is one of the most common monogenic diseases worldwide. Preimplantation genetic testing (PGT) of β-thalassemia is performed to avoid affected pregnancies has become increasingly popular worldwide. In which, the indirect analysis using short tandem repeat (STRs) linking with HBB gene to detect different β-globin (HBB) gene mutation is a simple, accurate, economical and also provides additional control of contamination and allele-drop-out ADO.
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