Dietary Ethanolic Extract of Mangosteen pericarp Reduces VCAM-1, Perivascular Adipose Tissue and Aortic Intimal Medial Thickness in Hypercholesterolemic Rat Model | Zendy

Titin Andri Wihastuti | Zendy; Fitria Nugraha Aini | Zendy; Cholid Tri Tjahjono | Zendy; Teuku Heriansyah | Zendy

Open Access

Dietary Ethanolic Extract of Mangosteen pericarp Reduces VCAM-1, Perivascular Adipose Tissue and Aortic Intimal Medial Thickness in Hypercholesterolemic Rat Model

Author(s) -

Titin Andri Wihastuti,

Fitria Nugraha Aini,

Cholid Tri Tjahjono,

Teuku Heriansyah

Publication year - 2019

Publication title -

open access macedonian journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.288

H-Index - 17

ISSN - 1857-9655

DOI - 10.3889/oamjms.2019.717

Subject(s) - vcam 1 , medicine , oxidative stress , dyslipidemia , endocrinology , adipose tissue , tunica intima , lipid profile , hyperlipidemia , obesity , cholesterol , cell adhesion molecule , diabetes mellitus , icam 1 , immunology , carotid arteries

High-fat diet (HFD) is associated with dyslipidemia which is a risk factor for atherosclerosis. Dyslipidemia causes oxidative stress which induces vascular cell adhesion molecule-1 (VCAM-1). Oxidative stress also triggers the thickening of tunica intima-media (IMT) and Perivascular Adipose Tissue (PVAT). Xanthone compound in ethanolic extract of Mangosteen pericarp (EEMP) has an antioxidant property to overcome the oxidative stress.

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