Correlation of CD8+ Expression, Foxp3+ Expression, and CD8+/Foxp3+ Ratio with Triple Negative Breast Cancer Stage in Sanglah General Hospital | Zendy

I Wayan Sudarsa | Zendy; Dewa Gede Subawa | Zendy; Putu Anda Tusta Adiputra | Zendy; Ida Bagus Tjakra Wibawa Manuaba | Zendy

Open Access

Correlation of CD8+ Expression, Foxp3+ Expression, and CD8+/Foxp3+ Ratio with Triple Negative Breast Cancer Stage in Sanglah General Hospital

Author(s) -

I Wayan Sudarsa,

Dewa Gede Subawa,

Putu Anda Tusta Adiputra,

Ida Bagus Tjakra Wibawa Manuaba

Publication year - 2019

Publication title -

open access macedonian journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.288

H-Index - 17

ISSN - 1857-9655

DOI - 10.3889/oamjms.2019.453

Subject(s) - medicine , breast cancer , foxp3 , triple negative breast cancer , oncology , cd8 , stage (stratigraphy) , tumor infiltrating lymphocytes , multivariate analysis , cancer , immunology , immune system , biology , paleontology

Triple negative breast cancer (TNBC) is a breast cancer sub-type that lacks ER, PR and HER-2 expression. This type tends to be more aggressive than other types of breast cancer, with poor prognosis, distant metastases, higher recurrence rate, and lower overall survival. The TNBC is resistant to hormonal therapy, but generally very susceptible to chemotherapy. Expression of CD8+ and Foxp3+ were parts of the TIL, which often found in TNBC as an immune response to tumour antigens following antigens presenting cell (APC) stimulation.

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