Immunohistochemical Expression of MMR Proteins with Clinicopathological Correlation in Colorectal Cancer in Egypt | Zendy

Nahed Soliman | Zendy; Deaa Fekri Morsi | Zendy; Noha A.H. Helmy | Zendy

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Immunohistochemical Expression of MMR Proteins with Clinicopathological Correlation in Colorectal Cancer in Egypt

Author(s) -

Nahed Soliman,

Deaa Fekri Morsi,

Noha A.H. Helmy

Publication year - 2019

Publication title -

open access macedonian journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.288

H-Index - 17

ISSN - 1857-9655

DOI - 10.3889/oamjms.2019.357

Subject(s) - microsatellite instability , medicine , msh6 , pms2 , lynch syndrome , msh2 , immunohistochemistry , colorectal cancer , perineural invasion , dna mismatch repair , signet ring cell , mlh1 , lymphovascular invasion , pathology , oncology , stage (stratigraphy) , adenocarcinoma , cancer , metastasis , biology , microsatellite , allele , gene , paleontology , biochemistry

Microsatellite instability (MSI) is the genetic pathway underlying 15% of sporadic colorectal carcinoma (CRC) and hereditary non-polyposis CRC. MSI-H CRC has a distinct clinicopathological characteristic including excess mucin and signet ring component, proximal colon, Crohn's like reaction, lymphocytic infiltration, and better survival.

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