Evaluation of APOE Genotype and Vascular Risk Factors As Prognostic and Risk Factors for Alzheimer’s Disease and Their Influence On Age of Symptoms Onset | Zendy

Gabriela Novotni | Zendy; Milena Jakimovska | Zendy; Dijana PlaseskaKaranfilska | Zendy; Nikolina Tanovska | Zendy; Igor Kuzmanovski | Zendy; Vasko Aleksovski | Zendy; Katerina Karanfilovik | Zendy; Natalija Baneva-Dolnenec | Zendy; Marijana Stankovic | Zendy; Milos Milutinovik | Zendy; Svetlana Iloski | Zendy; Rosalinda Isjanovska | Zendy; Biljana Blaževska–Stoilkovska | Zendy; A. Duma | Zendy; Antoni Novotni | Zendy

Open Access

Evaluation of APOE Genotype and Vascular Risk Factors As Prognostic and Risk Factors for Alzheimer’s Disease and Their Influence On Age of Symptoms Onset

Author(s) -

Gabriela Novotni,

Milena Jakimovska,

Dijana PlaseskaKaranfilska,

Nikolina Tanovska,

Igor Kuzmanovski,

Vasko Aleksovski,

Katerina Karanfilovik,

Natalija Baneva-Dolnenec,

Marijana Stankovic,

Milos Milutinovik,

Svetlana Iloski,

Rosalinda Isjanovska,

Biljana Blaževska–Stoilkovska,

A. Duma,

Antoni Novotni

Publication year - 2019

Publication title -

open access macedonian journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.288

H-Index - 17

ISSN - 1857-9655

DOI - 10.3889/oamjms.2019.166

Subject(s) - medicine , apolipoprotein e , diabetes mellitus , dementia , disease , risk factor , dyslipidemia , vascular dementia , genotyping , type 2 diabetes mellitus , genotype , allele , endocrinology , genetics , gene , biology

Alzheimer's disease (AD), the most common cause of dementia, is evolving to become a threatening epidemy of the 21 st century. Only 21% of the predicted number of AD patients in Macedonia have been diagnosed and treated, which means that almost 80% are underdiagnosed or misdiagnosed. Apolipoprotein E gene ( APOE ) is recognised as the strongest genetic risk factor for sporadic AD. Whether and when Alzheimer's disease develops, depends on the very complex interaction between genetic and modifiable risk factors. It has been known that vascular factors like hypertension, diabetes mellitus, hypercholesterolemia and obesity increase the risk of developing both AD, vascular dementia and mixed AD and vascular pathology.

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