The The Influence of Wharton Jelly Mesenchymal Stem Cell toward Matrix Metalloproteinase-13 and RELA Synoviocyte Gene Expression on Osteoarthritis | Zendy

Vivi Sofia | Zendy; Ellyza Nasrul | Zendy; Menkher Manjas | Zendy; Gusti Revilla | Zendy

Open Access

The The Influence of Wharton Jelly Mesenchymal Stem Cell toward Matrix Metalloproteinase-13 and RELA Synoviocyte Gene Expression on Osteoarthritis

Author(s) -

Vivi Sofia,

Ellyza Nasrul,

Menkher Manjas,

Gusti Revilla

Publication year - 2019

Publication title -

open access macedonian journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.288

H-Index - 17

ISSN - 1857-9655

DOI - 10.3889/oamjms.2019.157

Subject(s) - medicine , osteoarthritis , gene expression , mesenchymal stem cell , pathogenesis , cartilage , andrology , gene , pathology , immunology , microbiology and biotechnology , biology , anatomy , genetics , alternative medicine

Therapy for osteoarthritis (OA) with satisfactory results has not been found to date. In OA pathogenesis, RELA gene involved in cartilage degradation and MMP-13 in degrade cartilage, as a member family of NF-κβ genes, RELA serves to modulate inflammatory responses and activates pro-inflammatory cytokines.

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