Hypoxia-preconditioned MSCs Have Superior Effect in Ameliorating Renal Function on Acute Renal Failure Animal Model | Zendy

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Hypoxia-preconditioned MSCs Have Superior Effect in Ameliorating Renal Function on Acute Renal Failure Animal Model

Author(s) -

Agung Putra,

Danis Pertiwi,

Meidourul Milla,

Ulfah Dian Indrayani,

Durotul Jannah,

Menik Sahariyani,

Setyo Trisnadi,

Joko Wahyu Wibowo

Publication year - 2019

Publication title -

open access macedonian journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.288

H-Index - 17

ISSN - 1857-9655

DOI - 10.3889/oamjms.2019.049

Subject(s) - medicine , creatinine , renal function , blood urea nitrogen , nephrotoxicity , urology , mesenchymal stem cell , dialysis , kidney , hypoxia (environmental) , pharmacology , endocrinology , pathology , chemistry , organic chemistry , oxygen

Acute renal failure (ARF) is a serious disease characterised by a rapid loss of renal functions due to nephrotoxic drug or ischemic insult. The clinical treatment approach such as dialysis techniques and continuous renal enhancement have grown rapidly during past decades. However, there is yet no significant effect in improving renal function. Hypoxia-preconditioned mesenchymal stem cells (HP-MSCs) have positive effects on the in vitro survival and stemness, in addition to angiogenic potential.

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