Balinese Cultivar of Purple Sweet Potato Improved Neurological Score and BDNF and Reduced Caspase-Independent Apoptosis among Wistar Rats with Ischemic Stroke | Zendy

I Made Oka Adnyana | Zendy; Raka Sudewi | Zendy; Purwa Samatra | Zendy; Dewa Ngurah Suprapta | Zendy

Open Access

Balinese Cultivar of Purple Sweet Potato Improved Neurological Score and BDNF and Reduced Caspase-Independent Apoptosis among Wistar Rats with Ischemic Stroke

Author(s) -

I Made Oka Adnyana,

Raka Sudewi,

Purwa Samatra,

Dewa Ngurah Suprapta

Publication year - 2019

Publication title -

open access macedonian journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.288

H-Index - 17

ISSN - 1857-9655

DOI - 10.3889/oamjms.2019.019

Subject(s) - medicine , neuroprotection , antioxidant , apoptosis , anthocyanin , stroke (engine) , programmed cell death , reactive oxygen species , pharmacology , botany , biochemistry , biology , mechanical engineering , engineering

Ischemic stroke occurs due to the abrupt occlusion in the brain which leads to neuronal death. Neuronal death in ischemic stroke is due to increase production of reactive oxygen species (ROS). Neuronal death occurs via necrosis and apoptosis mechanisms. Apoptosis can either occur via extrinsic or intrinsic pathway. Meanwhile, the intrinsic pathway can be caspase-dependent or independent. Anthocyanin is a natural pigment with antioxidant, anti-inflammatory, anti-cancer, and neuroprotective properties. Balinese cultivate of purple potato extract contains a high level of anthocyanin and has been proven for its antioxidant activity.

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