High Il-1β Serum as a Predictor of Decreased Cognitive Function in Mild Traumatic Brain Injury Patients | Zendy

Dewa Putu Gede Purwa Samatra | Zendy; Ni Made Dwita Pratiwi | Zendy; I Putu Eka Widyadharma | Zendy

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High Il-1β Serum as a Predictor of Decreased Cognitive Function in Mild Traumatic Brain Injury Patients

Author(s) -

Dewa Putu Gede Purwa Samatra,

Ni Made Dwita Pratiwi,

I Putu Eka Widyadharma

Publication year - 2018

Publication title -

open access macedonian journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.288

H-Index - 17

ISSN - 1857-9655

DOI - 10.3889/oamjms.2018.390

Subject(s) - medicine , traumatic brain injury , cognition , prospective cohort study , hippocampus , pathophysiology , anesthesia , psychiatry

Traumatic brain injury (TBI) exerts a significant impact on society with regards to physical, affective, and cognitive impairment. The consequent cognitive sequelae include a problem in memory, attention, concentration, and processing speed. Following traumatic brain injury, inflammatory response developed, characterised by increased interleukin 1-β (IL-1β) levels in the blood. IL 1-β at pathophysiological concentration has been reported to cause an inhibition of the expression of long-term potentiation (LTP) in the areas CA1, CA3, and dentate gyrus of the hippocampus.

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