TP53 Mutation in Correlation to Immunohistochemical Expression of P53 Protein in Patients with Hepatocellular Carcinoma | Zendy

Dafiikolova | Zendy; Viktorija Chalovska-Ivanova | Zendy; Magdalena Genadieva-Dimitrova | Zendy; Aleksandar Eftimov | Zendy; Rubens Jovanovik | Zendy; Vesna Janevska | Zendy

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TP53 Mutation in Correlation to Immunohistochemical Expression of P53 Protein in Patients with Hepatocellular Carcinoma

Author(s) -

Dafiikolova,

Viktorija Chalovska-Ivanova,

Magdalena Genadieva-Dimitrova,

Aleksandar Eftimov,

Rubens Jovanovik,

Vesna Janevska

Publication year - 2018

Publication title -

open access macedonian journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.288

H-Index - 17

ISSN - 1857-9655

DOI - 10.3889/oamjms.2018.278

Subject(s) - hepatocellular carcinoma , medicine , missense mutation , sanger sequencing , gene , exon , gene mutation , cirrhosis , mutation , immunohistochemistry , point mutation , cancer research , pathology , polymerase chain reaction , biology , genetics

Mutations causing p53 inactivation are among the most common genetic alterations in human malignant tumours including hepatocellular carcinoma. Detection of p53 gene mutations in patients with hepatocellular carcinoma (HCC) should provide relevant data for the patients from the Republic of Macedonia and should allow the survivals additional therapeutic option as is gene therapy.

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