Effect of a Histone Deacetylases Inhibitor of IL-18 and TNF-Alpha Secretion in Vitro | Zendy

Zlatka Georgieva Dobreva | Zendy; Boncho Grigorov | Zendy; Spaska Stanilova | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Effect of a Histone Deacetylases Inhibitor of IL-18 and TNF-Alpha Secretion in Vitro

Author(s) -

Zlatka Georgieva Dobreva,

Boncho Grigorov,

Spaska Stanilova

Publication year - 2018

Publication title -

open access macedonian journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.288

H-Index - 17

ISSN - 1857-9655

DOI - 10.3889/oamjms.2018.075

Subject(s) - proinflammatory cytokine , tumor necrosis factor alpha , medicine , secretion , inflammasome , peripheral blood mononuclear cell , cytokine , immune system , interleukin , immunology , microbiology and biotechnology , cancer research , endocrinology , biology , in vitro , inflammation , biochemistry

Interleukin-18 (IL-18) and Tumor Necrosis Factor-alpha (TNF-α) are proinflammatory cytokines that increased the development of Th1 immune response, but have a different type of regulation of the gene expression. Whereas TNF-α has an inducible expression, IL-18 is translated as an inactive protein and required proteolytic cleavage by Casp-1 in inflammasome complexes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research