Detection of gyrA Mutation Among Clinical Isolates of Campylobacter jejuni Isolated in Egypt by MAMA-PCR | Zendy

Mayar Maged Said | Zendy; Hanan El-Mohamady | Zendy; Fawkia M. El-Beih | Zendy; David Rockabrand | Zendy; Tharwat F. Ismail | Zendy; Marshall R. Monteville | Zendy; Salwa F. Ahmed | Zendy; John D. Klena | Zendy; Mohamed Salama | Zendy

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Detection of gyrA Mutation Among Clinical Isolates of Campylobacter jejuni Isolated in Egypt by MAMA-PCR

Author(s) -

Mayar Maged Said,

Hanan El-Mohamady,

Fawkia M. El-Beih,

David Rockabrand,

Tharwat F. Ismail,

Marshall R. Monteville,

Salwa F. Ahmed,

John D. Klena,

Mohamed Salama

Publication year - 2010

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.963

Subject(s) - campylobacter jejuni , campylobacter , microbiology and biotechnology , ciprofloxacin , nalidixic acid , biology , campylobacter coli , dna gyrase , quinolone , antibiotics , gene , genetics , bacteria , escherichia coli

Campylobacter spp are the major cause of enteritis in humans and more than 90% of reported infections are caused by Campylobacter jejuni. Fluoroquinolones such as ciprofloxacin are the antibiotics of choice for treatment. An increase in the frequency of ciprofloxacin-resistant Campylobacter has been reported globally due to a single base mutation (C-257 to T) in codon 86 of the quinolone resistance determining region (QRDR) of the gyrA gene altering the amino acid sequence from threonine at position 86 to isoleucine (Thr-86 to Ile).

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