A rare fatal case of a novel bunyavirus-associated hemophagocytic lymphohistiocytosis | Zendy

Ling Lin | Zendy; Youzu Xu | Zendy; Xiaomai Wu | Zendy; Hongfei Ge | Zendy; Jia-Xi Feng | Zendy; MeiFang Chen | Zendy; Dongqing Lv | Zendy; Boli Li | Zendy; Jian Lin | Zendy

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A rare fatal case of a novel bunyavirus-associated hemophagocytic lymphohistiocytosis

Author(s) -

Ling Lin,

Youzu Xu,

Xiaomai Wu,

Hongfei Ge,

Jia-Xi Feng,

MeiFang Chen,

Dongqing Lv,

Boli Li,

Jian Lin

Publication year - 2016

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.7268

Subject(s) - hemophagocytic lymphohistiocytosis , cytopenia , leukocytopenia , severe fever with thrombocytopenia syndrome , medicine , case fatality rate , pediatrics , bone marrow , disease , immunology , surgery , epidemiology , chemotherapy , virus

Herein we describe a rare fatal case of a novel bunyavirus-associated hemophagocytic lymphohistiocytosis (HLH) in a 62-year-old female patient. The novel bunyavirus infects patients with or without HLH who have similar clinical features such as fever, thrombocytopenia, and leukocytopenia. Therefore, the diagnosis of HLH can be easily missed. When HLH occurs, the disease worsens and the fatality rate rises. Our finding highlights the importance of bone marrow biopsy performed as soon as possible for patients suspected of having a novel bunyavirus infection and showing marked cytopenia in three cell lines.

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