Frequency of mutational changes in the embB among the ethambutol-resistant strains of Mycobacterium tuberculosis in Iran | Zendy

Faranak Rezaei | Zendy; Mehri Haeili | Zendy; Parviz Mohajeri | Zendy; Abdolrazagh Hashemi Shahraki | Zendy; Abbas Ali Imani Fooladi | Zendy; Fatemeh Zahednamazi | Zendy; Mohammad Mehdi Feizabadi | Zendy

Open Access

Frequency of mutational changes in the embB among the ethambutol-resistant strains of Mycobacterium tuberculosis in Iran

Author(s) -

Faranak Rezaei,

Mehri Haeili,

Parviz Mohajeri,

Abdolrazagh Hashemi Shahraki,

Abbas Ali Imani Fooladi,

Fatemeh Zahednamazi,

Mohammad Mehdi Feizabadi

Publication year - 2016

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.7215

Subject(s) - ethambutol , mycobacterium tuberculosis , genotype , biology , tuberculosis , drug resistance , virology , genetics , multiple drug resistance , microbiology and biotechnology , gene , medicine , pathology

Early detection of drug resistant tuberculosis is one of the main priorities of TB control program. Ethambutol (EMB) is a first-line anti-TB drug that is effective for preventing treatment failures caused by Mycobacterium tuberculosis strains that are resistant to other drugs. The aim of this study was to sequence the embB gene to characterize the mutations causing resistance to EMB and to analyze the relationship between bacterial genotype and EMB resistance among M. tuberculosis isolates in Iran.

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