In silico identification of cytotoxic T lymphocyte epitopes encoded by RD5 region of Mycobacterium tuberculosis | Zendy

Junwei Zhao | Zendy; Min Yan | Zendy; Guang Shi | Zendy; Shulin Zhang | Zendy; Liang Ming | Zendy

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In silico identification of cytotoxic T lymphocyte epitopes encoded by RD5 region of Mycobacterium tuberculosis

Author(s) -

Junwei Zhao,

Min Yan,

Guang Shi,

Shulin Zhang,

Liang Ming

Publication year - 2017

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.7207

Subject(s) - epitope , ctl* , cytotoxic t cell , in silico , biology , mycobacterium tuberculosis , human leukocyte antigen , antigen , virology , tuberculosis , cd8 , population , immunology , genetics , medicine , gene , in vitro , environmental health , pathology

While CD8+ T cells (cytotoxic T lymphocytes, CTLs) play important roles in immunity against Mycobacterium tuberculosis, only a small number of human leukocyte differentiation antigen (HLA) class I-restricted CTL epitopes for TB have been identified. The current study evaluates CTL epitopes of Rv3117 and Rv3120 proteins, two newly found M. tuberculosis region-diffference-5 (RD5)-encoded antigens, and their population coverage.

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