The microRNA-let-7b-mediated attenuated strain of influenza A (H1N1) virus in a mouse model | Zendy

Mingming Tan | Zendy; Wenkui Sun | Zendy; Chunlai Feng | Zendy; Di Xia | Zendy; Xiaoyue Shen | Zendy; Yuan Hong Ding | Zendy; Zhicheng Liu | Zendy; Zheng Xing | Zendy; Xin Su | Zendy; Yi Shi | Zendy

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The microRNA-let-7b-mediated attenuated strain of influenza A (H1N1) virus in a mouse model

Author(s) -

Mingming Tan,

Wenkui Sun,

Chunlai Feng,

Di Xia,

Xiaoyue Shen,

Yuan Hong Ding,

Zhicheng Liu,

Zheng Xing,

Xin Su,

Yi Shi

Publication year - 2016

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.6861

Subject(s) - virus , virology , virulence , biology , gene silencing , influenza a virus , viral shedding , pathogenicity , microbiology and biotechnology , gene , biochemistry

Evaluating the attenuation of influenza viruses in animal studies is important in developing safe and effective vaccines. This study aimed to demonstrate that the microRNA (miRNA)-let-7b-mediated attenuated influenza viruses (miRT-H1N1) are sufficiently attenuated and safe in mice.

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