Molecular detection of DHFR gene polymorphisms in Pneumocystis jirovecii isolates from Indian patients | Zendy

Yogita Singh | Zendy; Bijay Ranjan Mirdha | Zendy; Randeep Guleria | Zendy; Shehla Khalil | Zendy; Ashutosh Panda | Zendy; Rama Chaudhry | Zendy; Anant Mohan | Zendy; Sushil K. Kabra | Zendy; Lalit Kumar | Zendy; Sanjay Kumar Agarwal | Zendy

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Molecular detection of DHFR gene polymorphisms in Pneumocystis jirovecii isolates from Indian patients

Author(s) -

Yogita Singh,

Bijay Ranjan Mirdha,

Randeep Guleria,

Shehla Khalil,

Ashutosh Panda,

Rama Chaudhry,

Anant Mohan,

Sushil K. Kabra,

Lalit Kumar,

Sanjay Kumar Agarwal

Publication year - 2015

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.6810

Subject(s) - dihydropteroate synthase , pneumocystis jirovecii , dhps , biology , dihydrofolate reductase , pneumocystis pneumonia , gene , virology , nested polymerase chain reaction , ribosomal rna , pneumocystis carinii , polymerase chain reaction , microbiology and biotechnology , trimethoprim , genetics , pyrimethamine , immunology , human immunodeficiency virus (hiv) , antibiotics , plasmodium falciparum , malaria

Pneumocystis pneumonia (PCP) is an opportunistic life-threatening infection, especially for immunocompromised individuals. A trimethoprim-sulfamethoxazole (TMP-SMX) combination is commonly used for the treatment of PCP, targeting both dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) enzymes. Several studies have already shown that polymorphisms in the DHPS gene are associated with drug resistance. The present study analyzed DHFR gene polymorphisms in Pneumocystis jirovecii recovered from clinical samples from patients admitted to a tertiary care health center in New Delhi, India.

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