Inducible and constitutive clindamycin resistance in Staphylococcus aureus in a northeastern Indian tertiary care hospital | Zendy

Amit Banik | Zendy; Annie Bakorlin Khyriem | Zendy; Jeetendra Gurung | Zendy; Valarie Lyngdoh | Zendy

Open Access

Inducible and constitutive clindamycin resistance in Staphylococcus aureus in a northeastern Indian tertiary care hospital

Author(s) -

Amit Banik,

Annie Bakorlin Khyriem,

Jeetendra Gurung,

Valarie Lyngdoh

Publication year - 2015

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.6336

Subject(s) - clindamycin , staphylococcus aureus , microbiology and biotechnology , erythromycin , methicillin resistant staphylococcus aureus , incidence (geometry) , medicine , drug resistance , antimicrobial , antibiotics , antibiotic resistance , phenotype , biology , bacteria , gene , genetics , physics , optics , biochemistry

Staphylococcus aureus is one of the most common pyogenic bacteria. They are notorious for developing prompt resistance to newer antimicrobials. With increasing incidence of methicillin-resistant S. aureus (MRSA) isolates, the treatment options are also becoming limited. Clindamycin is an excellent drug for skin and soft tissue infections, but resistance mediated by the inducible phenotype (iMLS(B)) leads to in vivo therapeutic failure even though there may be in vitro susceptibility. The double disk approximation test (D-test) can reliably detect the presence of such isolates. This study was aimed to detect and report the prevalence of the iMLS(B) phenotype in NEIGRIHMS, a tertiary care center in Northeast India.

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