Relationship of interleukin-1B gene promoter region polymorphism with Helicobacter pylori infection and gastritis | Zendy

Ivy Bastos Ramis | Zendy; Júlia Silveira Vianna | Zendy; Priscila Cristina Bartolomeu Halicki | Zendy; C. Malavé Lara | Zendy; Thássia Fernanda Tadiotto | Zendy; João Batista da Silva Maciel | Zendy; Carla Vitola Gonçalves | Zendy; Andréa von Groll | Zendy; Odir Antônio Dellagostin | Zendy; Pedro Eduardo Almeida da Silva | Zendy

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Relationship of interleukin-1B gene promoter region polymorphism with Helicobacter pylori infection and gastritis

Author(s) -

Ivy Bastos Ramis,

Júlia Silveira Vianna,

Priscila Cristina Bartolomeu Halicki,

C. Malavé Lara,

Thássia Fernanda Tadiotto,

João Batista da Silva Maciel,

Carla Vitola Gonçalves,

Andréa von Groll,

Odir Antônio Dellagostin,

Pedro Eduardo Almeida da Silva

Publication year - 2015

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.6123

Subject(s) - caga , helicobacter pylori , gastritis , genotype , biology , gene polymorphism , gene , immunology , chronic gastritis , gastroenterology , medicine , genetics , virulence

Helicobacter pylori infection is associated with gastritis, peptic ulcer disease and gastric carcinoma. The severity of damage is determined by the interplay between environmental/behavioral factors, bacterial pathogenicity genes and host genetic polymorphisms that can influence the secretion levels of inflammatory cytokines. Accordingly, this study aimed to identify polymorphisms in the IL-1B and IL-1RN genes and their associations with H. pylori infection, cagA gene of H. pylori, and gastroduodenal diseases.

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