Low rifampicin concentrations in tuberculosis patients with HIV infection | Zendy

Tanuja N. Gengiah | Zendy; Julia Hillary Botha | Zendy; Deepak Soowamber | Zendy; Kogieleum Naidoo | Zendy; Salim S. Abdool Karim | Zendy

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Low rifampicin concentrations in tuberculosis patients with HIV infection

Author(s) -

Tanuja N. Gengiah,

Julia Hillary Botha,

Deepak Soowamber,

Kogieleum Naidoo,

Salim S. Abdool Karim

Publication year - 2014

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.4696

Subject(s) - slco1b1 , rifampicin , tuberculosis , medicine , gastroenterology , pharmacokinetics , human immunodeficiency virus (hiv) , pharmacology , immunology , genotype , pharmacogenetics , biology , gene , pathology , genetics

The efficacy of tuberculosis (TB) treatment in Human Immunodeficiency Syndrome (HIV) co-infected patients may be compromised by genetic and pharmacokinetic variation in drug disposition. Rifampicin is a critical component of TB treatment. We investigated the influence of drug transporter gene polymorphisms on rifampicin concentrations in TB-HIV co-infected patients in Durban, South Africa.

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