Dam and its role in pathogenicity of Salmonella enterica | Zendy

Mónica N. Giacomodonato | Zendy; Sebastián Hernán Sarnacki | Zendy; Mariángeles Noto Llana | Zendy; M. Cristina Cerquetti | Zendy

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Dam and its role in pathogenicity of Salmonella enterica

Author(s) -

Mónica N. Giacomodonato,

Sebastián Hernán Sarnacki,

Mariángeles Noto Llana,

M. Cristina Cerquetti

Publication year - 2009

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.465

Subject(s) - salmonella enterica , virulence , salmonella , pathogenicity island , virulence factor , biology , microbiology and biotechnology , methylation , dna methylation , gene , bacteria , gene expression , genetics

Dam methylation is an essential factor involved in the virulence of an increasing number of bacterial pathogens including Salmonella enterica. Lack of Dam methylation causes severe attenuation in animal models. It has been proposed that dysregulation of Dam activity is potentially a general strategy for the generation of vaccines against bacterial pathogens. In this review, we focus our attention on the role of methylation by Dam protein in regulating bacterial gene expression and virulence in Salmonella enterica.

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