CCR2, CX3CR1, RANTES and SDF1 genetic polymorphisms influence HIV infection in a Zimbabwean pediatric population | Zendy

Kudakwashe Mhandire | Zendy; Kerina Duri | Zendy; Gwendoline Kandawasvika | Zendy; Precious Chandiwana | Zendy; Nyasha Chin’ombe | Zendy; Russell B. Kanyera | Zendy; Babill StrayPedersen | Zendy; Collet Dandara | Zendy

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CCR2, CX3CR1, RANTES and SDF1 genetic polymorphisms influence HIV infection in a Zimbabwean pediatric population

Author(s) -

Kudakwashe Mhandire,

Kerina Duri,

Gwendoline Kandawasvika,

Precious Chandiwana,

Nyasha Chin’ombe,

Russell B. Kanyera,

Babill StrayPedersen,

Collet Dandara

Publication year - 2014

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.4599

Subject(s) - cx3cr1 , immunology , virology , population , human immunodeficiency virus (hiv) , medicine , biology , chemokine , chemokine receptor , environmental health , inflammation

There is growing evidence that polymorphisms in chemokine and chemokine receptor genes influence susceptibility to HIV infection and disease progression. However, not much is documented about the prevalence and effects of chemokine and chemokine receptor gene variations in the Zimbabwean population despite the high burden of HIV/AIDS in the country. This study therefore describes polymorphisms in CCR2, CX3CR1, SDF1 and RANTES genes in a Zimbabwean pediatric population and their effects on HIV infection in children born to HIV-infected mothers.

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