Differential Early Secreted Antigen Target (ESAT) 6 kDa–induced IFN-γ and SOCS1 expression distinguishes latent and active tuberculosis | Zendy

Kiran Iqbal Masood | Zendy; Rabia Hussain | Zendy; Nisar Ahmed Rao | Zendy; Martı́n E. Rottenberg | Zendy; Naseem Salahuddin | Zendy; Muhammad Irfan | Zendy; Zahra Hasan | Zendy

Open Access

Differential Early Secreted Antigen Target (ESAT) 6 kDa–induced IFN-γ and SOCS1 expression distinguishes latent and active tuberculosis

Author(s) -

Kiran Iqbal Masood,

Rabia Hussain,

Nisar Ahmed Rao,

Martı́n E. Rottenberg,

Naseem Salahuddin,

Muhammad Irfan,

Zahra Hasan

Publication year - 2014

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.3412

Subject(s) - esat 6 , suppressor of cytokine signaling 1 , mycobacterium tuberculosis , immunology , interferon gamma , medicine , tuberculin , tuberculosis , cytokine , latent tuberculosis , interferon , pathology , suppressor , cancer

Expression of Suppressor of cytokine signaling (SOCS)-1 molecules is increased in patients with tuberculosis (TB). Early Secreted Antigen Target (ESAT)-6 kDa - induced IFN-γ responses indicate Mycobacterium tuberculosis infection. The effect of ESAT6- stimulation on SOCS1 in the host is not known.

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