Evaluation of the immunogenicity and the protective efficacy in mice of a DNA vaccine encoding SP41 from Brucella melitensis | Zendy

Ayman Al-Mariri | Zendy; Abdul Qader Abbady | Zendy

Open Access

Evaluation of the immunogenicity and the protective efficacy in mice of a DNA vaccine encoding SP41 from Brucella melitensis

Author(s) -

Ayman Al-Mariri,

Abdul Qader Abbady

Publication year - 2013

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.2296

Subject(s) - brucella melitensis , dna vaccination , immunogenicity , brucella , biology , immune system , microbiology and biotechnology , virology , immunology , immunization , brucellosis

Brucella melitensis is a facultative intracellular Gram-negative bacterial pathogen that may enter the host via ingestion or inhalation, or through conjunctiva or skin abrasions. Some Brucella spp surface proteins (SPs) play an important role in bacterial adhesion and invasion and thus represent targets for the host immune system. Brucella spp surface protein with apparent molecular mass of 41 kDa interacts selectively with HeLa cells.

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